Thanks especially to generous donations, the Mendrisio Museum of Art can now boast a remarkable collection of paintings (including an important group of ex-voto), sculptures and works on paper ranging from the 16th to the 20th century, which document local art history in detail (Maestro della Natività, Giovan Battista Bagutti, Antonio Rinaldi, Filippo Franzoni, Luigi Rossi, Edoardo Berta, Guido Gonzato, Pietro Chiesa, Imre Reiner, Giuseppe Bolzani, Jean Corty, Edmondo Dobrzanski). Of major importance is the collected work of a leading figure in 20th-century art in Ticino and Lombardy, Pietro Chiesa, comprising, in addition to 500 paintings and drawings, the artist's own valuable records. The collection is further enriched by a body of work by prominent figures in Italian post-war art (Mario Sironi, Gino Severini, Fausto Pirandello, Atanasio Soldati, Ennio Morlotti, Tancredi Parmeggiani, Gianni Dova, Piero Gilardi).
The Museum also has in its keeping over 650 Trasparenti produced for Easter Week processions from the end of the 18th century to the present day. A legacy of extraordinary value, these constitute a unique historical and religious testimony of the region.